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  3. For some time scientists have believed that cholesterol plays a major role in heart disease because people with familial hyperch

For some time scientists have believed that cholesterol plays a major role in heart disease because people with familial hyperch

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问题     For some time scientists have believed that cholesterol plays a major role in heart disease because people with familial hypercholesterolemia, a genetic defect, have six to eight times the normal level of cholesterol in their blood and they invariably develop heart disease. These people lack cell-surface receptors for low-density lipoproteins (LDL’s), which are the fundamental carriers of blood cholesterol to the body cells that use cholesterol. Without an adequate number of cell-surface receptors to remove LDL’s from the blood, the cholesterol-carrying LDL’s remain in the blood, increasing blood cholesterol levels. Scientists also noticed that people with familial hypercholesterolemia appear to produce more LDL’s than normal individuals. How, scientists wondered, could a genetic mutation that causes a slowdown in the removal of LDL’s from the blood also result in an increase in the synthesis of this cholesterol-carrying protein?
    Since scientists could not experiment on human body tissue, their knowledge of familial hypercholesterolemia was severely limited. However, a breakthrough came in the laboratories of Yoshio Watanabe of Kobe University in Japan in 1980. Watanabe noticed that a male rabbit in his colony had ten times the normal concentration of cholesterol in its blood. By appropriate breeding, Watanabe obtained a strain of rabbits that had very high cholesterol levels. These rabbits spontaneously developed heart disease. To his surprise, Watanabe further found that the rabbits, like humans with familial hypercholesterolemia, lacked LDL receptors. Thus, scientists could study these Watanabe rabbits to gain a better understanding of familial hypercholesterolemia in humans.
    Prior to the breakthrough at Kobe University, it was known that LDL’s are secreted from the liver in the form of a precursor, called very low-density lipoproteins (VLDL’s), which carry triglycerides as well as relatively small amounts of cholesterol. The triglycerides are removed from the VLDL’s by fatty and other tissues. What remains is a remnant particle that must be removed from the blood. What scientists learned by studying the Watanabe rabbits is that the removal of the VLDL remnant requires the LDL receptor. Normally, the majority of the VLDL remnants go to the liver where they bind to LDL receptors and are degraded. In the Watanabe rabbit, due to a lack of LDL receptors on liver cells, the VLDL remnants remain in the blood and are eventually converted to LDL’s. The LDL receptors thus have a dual effect in controlling LDL levels. They are necessary to prevent over synthesis of LDL’s from VLDL remnants and they are necessary for the normal removal of LDL’s from the blood. With this knowledge, scientists are now well on the way toward developing drugs that dramatically lower cholesterol levels in people afflicted with certain forms of familial hypercholesterolemia.
The passage supplies information to answer which of the following questions?
选项 A、Which body cells are the primary users of cholesterol?
B、How did scientists discover that LDL’s are secreted from the liver in the form of a precursor?
C、Where in the body are VLDL remnants degraded?
D、Which body tissues produce triglycerides?
答案C
解析 细节题。根据第三段，Normally, the majority of the VLDL remnants go to the liver where they bind to LDL receptors and are degraded.(正常情况下，大部分超低密度脂蛋白(VLDL)残余到达肝脏，在那里和低密度脂蛋白(LDL)受体融合并被降解。)所以选C。
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