We must begin testing this instrument, no matter______difficult it is.

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问题 We must begin testing this instrument, no matter______difficult it is.

选项 A、however
B、how
C、whatever
D、what

答案B

解析 however(无论怎样)相当于no matter how,how后跟形容词或副词;whatever(无论什么)相当于no matter what,what常修饰名词,也可在句中作主语、宾语、表语。根据句意并分析句子结构可知,选B。
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