首页
外语
计算机
考研
公务员
职业资格
财经
工程
司法
医学
专升本
自考
实用职业技能
登录
考研
Status of Gene Therapy At 18, Ashanthi Desilva of suburban Cleveland is a living symbol of one of the greater intellectual a
Status of Gene Therapy At 18, Ashanthi Desilva of suburban Cleveland is a living symbol of one of the greater intellectual a
admin
2013-05-04
60
问题
Status of Gene Therapy
At 18, Ashanthi Desilva of suburban Cleveland is a living symbol of one of the greater intellectual achievements of the 20th century. Born with an extremely rare and usually fatal disorder that left her without a functioning immune system (the "bubble-boy disease", named after an earlier victim who was kept alive for years in a sterile plastic ten), she was treated beginning in 1990 with a revolutionary new therapy that sought to correct the defect at its very source, in the genes of her white blood cells. It worked. Although her last gene-therapy treatment was in 1992, she is completely healthy with normal immune function, according to one of the doctors who treated her, W. French Anderson of the University of Southern California. Researchers have long dreamed of treating diseases from hemophilia to cancer by replacing mutant genes with normal ones. And the dreaming may continue for decades more. "There will be a gene-based treatment for essentially every disease," Anderson says, "within 50 years."
It’s not entirely clear why medicine has been so slow to build on Anderson’s early success. The National Institutes of Health budget office estimates it will spend $ 432 million on gene-therapy research in 2005, and there is no shortage of promising leads. The therapeutic genes are usually delivered through viruses that don’t cause human disease. "The virus is sort of like a Trojan Horse," says Ronald Crystal of New York Presbyterian/ Weill Cornell Medical College. "The cargo is the gene. "
At the University of Pennsylvania’s Abra-mson Cancer Center, immunologist Carl June recently treated HIV patients with a gene intended to help their cells resist the infection. At Cornell University, researchers are pursuing gene-based therapies for Parkinson’s disease and a rare hereditary disorder that destroys children’s brain cells. At Stanford University and the Children’s Hospital of Philadelphia, researchers are trying to figure out how to help patients with hemophilia who today must inject themselves with expensive clotting drugs for life. Animal experiments have shown great promise.
But somehow, things get lost in the translation from laboratory to patient. In human trials of the hemophilia treatment, patients show a response at first, but it fades over time. And the field has still not recovered from the setback it suffered in 1999, when Jesse Gelsinger, an 18-year-old with a rare metabolic disorder, died after receiving an experimental gene therapy at the University of Pennsylvania. Some experts worry that the field will be tarnished further if the next people to benefit are not patients but athletes seeking an edge. This summer, researchers at the Salk Institute in San Diego said they had created a " marathon mouse" by implanting a gene that enhances running ability; already, officials at the World Anti-Doping Agency are preparing to test athletes for signs of " gene doping". But the principle is the same, whether you’re trying to help a healthy runner run faster or allow a muscular-dystrophy patient to walk. "Everybody recognizes that gene therapy is a very good idea," says Crystal. "And eventually it’s going to work. "
The case of Ashanthi Desilva is mentioned in the text to______.
选项
A、show the promise of gene-therapy
B、give an example of modern treatment for fatal diseases
C、introduce the achievement of Anderson and his team
D、explain how gene-based treatment works
答案
A
解析
事实细节题。文章第一句对用基因疗法治疗Ashanthi所患罕见疾病的成功给予了很高的评价,并在第一段末指出医生们对:基因疗法寄予了极高的期望。由此可见,答案应该是[A]。
转载请注明原文地址:https://kaotiyun.com/show/2Cd4777K
0
考研英语一
相关试题推荐
GregFocker,playedbyBenStiller,representsagenerationofAmericankids(1)_____inthe1980sonthephilosophythatanyac
GregFocker,playedbyBenStiller,representsagenerationofAmericankids(1)_____inthe1980sonthephilosophythatanyac
Oneofyourclosefriends,Catherine,gaveapianosoloataconcertlastnightandwonthefirstprize.Nowwriteheraletter
MuchoftheAmericananxietyaboutoldageisaflightfromtherealityofdeath.OneofthestrikingqualitiesoftheAmerican
TheauthordoesnotincludeamongthesciencesthestudyofThetitlewhichbestexpressestheideaofthistextis
Accordingtothenewschoolofscientists,technologyisanoverlookedforceinexpandingthehorizonsofscientificknowledge.
Inanidealworld,thenation’seliteschoolswouldenrollthemostqualifiedstudents.Butthat’snothowit(1)_____.Applicant
AllSumeriancitiesrecognizedanumberofgodsincommon,includingtheskygod,thelordofstorms,andthemorningandevenin
AllSumeriancitiesrecognizedanumberofgodsincommon,includingtheskygod,thelordofstorms,andthemorningandevenin
[A]Anti-virussoftwareoftenbouncesawarningbacktothesenderofaninfectede-mail,sayingthatthee-mailinquestioncan
随机试题
基本的网络拓扑结构可以分为:________、________、________、________和________。
属于ⅠB类药物的抗心律失常药是:
A.球部B.胃或十二指肠后壁C.胃角和胃窦小弯D.胃或十二指肠前壁胃溃疡多位于
局部义齿基托折断不会是因为
A.肝B.心C.脾D.肺E.肾
长上公司与艺海公司在履行合同过程中发生了纠纷。长上公司按照仲裁条款向选定的石家庄市仲裁委员会提交了仲裁申请。下列关于该案仲裁庭的组成的表述哪个是错误的?
房间净高测量每个房间不少于5处,测量部位宜在距墙角(纵横墙交界处)()mm处及房间几何中心处。
建设工程造价咨询合同一般包括( )。
一年多以前,市政当局宣布警察将对非法停车进行严厉打击,将从写超速处罚单的人员中抽出更多资源以对非法停车开单处罚,但是并没有产生任何效果。警察局局长声称,必须从写超速处罚单的警察中抽出一部分人来打击本市非常严重的毒品问题。然而,警察们一如既往地写了许多超速处
Inhisautobiography,Darwinhimselfspeaksofhisintellectualpowerswithextraordinarymodesty.Hepointsoutthathealways
最新回复
(
0
)