Those with health problems should exercise regularly to maintain good health, no matter______busy they are.

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问题 Those with health problems should exercise regularly to maintain good health, no matter______busy they are.

选项 A、so
B、if
C、where
D、how

答案D

解析语法：副词1．空格内应填入一个副词，修饰后面的形容词，因此(D)how为正确选项。2．No matter可以和how，what，where等疑问词连用，语义上表示让步。

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