In the early 1450s cultural change in Europe fueled a growing need for the rapid and cheap production of written documents. Be

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问题   In the early 1450s cultural change in Europe fueled a growing
need for the rapid and cheap production of written documents.
Before this time, scribal monks hand-copied sacred texts for
centuries. But for the secular world began to develop and   【M1】______
distribute new forms of sacred texts, the scribes could not keep up
the demand. Johannes Gutenberg, a goldsmith and businessman 【M2】______
from southern Germany, foresees the profit-making potential for a   【M3】______
printing press that used movable metal type, and borrowed money
to develop that we know now as the modern printing press. He 【M4】______
developed his press by combing features of existed technologies: 【M5】______
textile, papermaking and wine presses.
  Perhaps his most significant innovation, therefore, was the  【M6】______
efficient molding and casting of movable metal type. Gutenberg
designed a Latin print Bible which became his most famous
work. Despite of the dramatic success of his printing press, 【M7】______
Gutenberg managed to default on a loan and lost his whole printing
establishment. His techniques were made publicly and his creditor   【M8】______
won the rights to the proceeds from the Gutenberg Bibles.
  In 1476, William Caxton set up England’s first printing
press. Caxton had been a prolific translator and found the printing
press to be a marvelousway to expand his mission of promoting
unpopular literature, the innovation of the printing press ultimately   【M9】______
influenced art, literature, philosophy and politics. Today,
print is thought of as one of the markers of key historical shifts in  【M10】______
communication, creating a social and intellectual transform.
【M6】

选项

答案therefore改成however

解析 上一句指出“他将纺织、造纸、榨葡萄汁的现有技术特点组合起来,发展了印刷术”。本句意为“也许,他最有意义的发明是活动金属块的成型和铸造技术”,两句之间无因果关系,应为转折关系。
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