______how difficult the situation may seem, it is very important to remember that there are others who are in worse situations.

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问题 ______how difficult the situation may seem, it is very important to remember that there are others who are in worse situations.

选项 A、As if
B、Even so
C、As though
D、No matter

答案D

解析 ——how difficult the situation may seem是让步状语从句,横线处应填入从属连词。因在difficult the situation may seem中,表语difficult置于主语the situation前,故how应是连词词组。故(D)no matter最恰当。no matter how=however。
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