_______, failure to respond promptly to the inquiry from that demanding customer will damage your business.

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问题 _______, failure to respond promptly to the inquiry from that demanding customer will damage your business.

选项 A、Without a doubt
B、Regardless
C、Only if
D、By no means

答案A

解析空格放在句首，并且后面有逗号。这时就应该填入副词。B选项是形容词，C选项是连词，所以排除。A、D选项都是“介词+名词”的形式，可以起到副词的作用。但D选项通常是以“By no means+动词+主语”的倒装形式使用，并没有逗号。A选项和certainly同义，经常在句首独立使用。

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