______is known to all, too much stress can cause disease.

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问题 ______is known to all, too much stress can cause disease.

选项 A、Which
B、That
C、It
D、As

答案D

解析分析句子结构可知，逗号前面为非限制性定语从句，应用as引导，指代整个主句的内容，可位于句首、句中和句末。也可将as is known to all(众所周知)当作固定搭配。类似的用法还有as is often the case(情况往往是这样)，as often happens(事情往往如此)，as is mentioned above(正如上面所提到的)等。故选D。

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本试题收录于：英语题库普高专升本分类