Cigarettes leave you with more than a smoky scent on your clothes and fingernails. A new study has found evidence tobacco 【M1】__

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问题     Cigarettes leave you with more than a smoky scent on your
clothes and fingernails. A new study has found evidence tobacco 【M1】______
use can chemically modify and effect the activity of genes known 【M2】______
to increase the risk of developing cancer. The finding may give
researchers a new tool to assessing cancer risk among people who 【M3】______
smoke.
    DNA isn’t destiny. Chemical compounds that affect the
functioning of genes can bind to our genetic material, turning
certain genes on or of. These so-called epigenetic modifications 【M4】______
can influence variety of traits, such as obesity and sexual 【M5】______
preference. Scientists have even identified specific epigenetic
patterns on the genes of people who smoke. None of the modified
genes has a direct link to cancer, therefore, making it unclear 【M6】______
whether these chemical alterations increase the risk of developing
the disease.
    In the new study, publishing in Human Molecular Genetics, 【M7】______
researchers analyzed epigenetic signatures in blood cells from 374
individuals enrolled in the European Prospective Investigation
into Cancer and Nutrition. EPIC, which it’s known, is a massive 【M8】______
study aimed at linking diet, lifestyle, and environmental factors to
the incident of cancer and other chronic diseases. Half of the 【M9】______
group consisted in people who went on to develop colon or breast 【M10】______
cancer 5 to 7 years after first joining the study, whereas the other
half remained healthy.
【M4】

选项

答案of—off

解析 形近词错误。该句的意思是影响基因功能的化学合成物能够与我们的基因物质结合,从而使某些基因发挥作用或失去作用。与turn on相对的是turn off,表示“关闭”。
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