首页
外语
计算机
考研
公务员
职业资格
财经
工程
司法
医学
专升本
自考
实用职业技能
登录
外语
Sleep deprivation is a quick and efficient way to treat depression. It works 60 to 70 percent of the time — far better than exis
Sleep deprivation is a quick and efficient way to treat depression. It works 60 to 70 percent of the time — far better than exis
admin
2020-08-26
21
问题
Sleep deprivation is a quick and efficient way to treat depression. It works 60 to 70 percent of the time — far better than existing drugs — but the mood boost usually lasts only until the patient falls asleep. As an ongoing treatment, sleep deprivation is impractical, but researchers have been studying the phenomenon in an effort to uncover the cellular mechanisms behind depression and
remission
. Now a team at Tufts University has pinpointed glia as the key players.
The researchers previously found that astrocytes, a star-shaped type of glial cell, regulate the brain chemicals involved in sleepiness. During our waking hours, astrocytes continuously release the neurotransmitter adenosine, which builds up in the brain and causes " sleep pressure," the feeling of sleepiness and its related memory and attention impairments. The neurotransmitter causes this pressure by binding to adenosine receptors on the outside of neurons like a key fitting into a lock. As more adenosine builds up, more receptors are triggered, and the urge to sleep gets stronger.
In the new study, published online January 15 in the journal Translational Psychiatry, the scientists investigated whether this process is responsible for the antidepressant effects of sleep deprivation. Mice with depressive-like symptoms were administered three doses of a compound that triggers adenosine receptors, thus mimicking sleep deprivation. Although the mice continued to sleep normally, after 12 hours they showed a rapid improvement in mood and behavior, which lasted for 48 hours.
The results confirm that the adenosine buildup is responsible for the antidepressant effects of a lack of sleep. This finding points to a promising target for new drug development because it suggests that mimicking sleep deprivation chemically may offer the antidepressant benefits without the unwanted side effects of actually skipping sleep. Such an intervention could offer immediate relief from depression, in stark contrast with traditional antidepressants, which take six to eight weeks to kick in.
The study may also have implications beyond depression and sleep regulation, according to Dustin Hines, lead author and a postdoctoral fellow at Tufts. " For many years, neuroscientists focused almost exclusively on neurons, whereas the role of glia was neglected," Hines says. "We now know that glia play an important role in the control of brain function and have the potential to aid in the development of new treatments for many illnesses, including depression and sleep disorders."
Dustin Hines and his colleagues did the study in order to_________.
选项
A、investigate the causes of depression
B、examine the working mechanisms of glia
C、explore why sleep deprivation relieves depression
D、test the medication effect of the new antidepressants
答案
C
解析
本题是细节题,要求考生在阅读完文章第三段第一句话之后能够准确理解该研究的目的。关键点在“…the scientists investigated whether this process is responsible for the antidepressant effects of sleep deprivation”处。
转载请注明原文地址:https://kaotiyun.com/show/5PTO777K
0
考博英语
相关试题推荐
Anytroopofwildanimalsshouldbeapproachedwarily.
Recentresearchfromanimalbehavioristssuggeststhat"asthecrowflies"shouldnolongerbetakentomean"theshortestdista
Thechiefeditorthoughthetooksomelibertieswiththeoriginalintranslation.Soitwasnecessarythathemakethe______sugg
Earlylastyearthecompanyresearchedthepossibilityof______anewlate-nightshow.
Thedevelopmentofwritingwasoneofthegreathumaninventions.Itisdifficult【C1】______manypeopletoimaginelanguagewitho
Hewas______tobeacollegegraduatebutheknewnothingabouthistory.
______bothinworkinglifeandeverydaylivingtodifferentsetsofvalues,andexpectationsplacesaseverestrainontheindiv
InNovember1987thegovernment______apublicdebateonthefuturedirectionoftheofficialsportspolicy.(2008年四川大学考博试题)
Theboycouldnotreconcilehimselftothefailure.Hedidnotbelievethatwashislot.
TheCommitteepronouncedfourmembersexpelledforfailuretoprovideinformationinthe______ofinvestigations.
随机试题
钛及钛合金焊件酸洗后放到洁净、干燥的环境中储存,储存时间不超过()h。
中度哮喘发作时下述检测结果可能有误的是()
若在对数期50min时测得大肠杆菌数为1.0×104cfu/mL,培养450min时大肠杆菌数为1.0×1011cfu/mL,则该菌的细胞生长繁殖速率为()。
买卖进出口许可证的判处罚金,不追究刑事责任。
转股价格应不低于募集说明公告日前______个交易日公司股票交易均价和前______个交易日的均价。( )
关于医嘱的处理,不正确的是()。
简述内外均衡理论的基本思想。
(2011年单选44)依据秦朝诉讼法律制度,下列选项中属于“非公室告”案件的是()。
甲接受乙的委托,为乙画了一幅肖像画。双方未就这幅画的归属作出约定。乙去世后,其继承人丙将这幅画卖给不知情的丁,则下列表述错误的是
WhereistheexperimentalAIDSvaccinetested?Whatistheauthor’sideaaboutAIDS?
最新回复
(
0
)