2. 外语
  3. A. severe B. generally C. treatment D. mistaken E. challenges F. disapprove G. matter H. rigorous I. magic J. suspected K. pub

A. severe B. generally C. treatment D. mistaken E. challenges F. disapprove G. matter H. rigorous I. magic J. suspected K. pub

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问题 A. severe B. generally C. treatment D. mistaken E. challenges
F. disapprove G. matter H. rigorous I. magic J. suspected
K. publically L. factors M. faulty N. based O. questioned
   Scientists have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.
   Since 2007, researchers have known that a gene called FTO was related to obesity, but they didn’t know how, and could not tie it to appetite or other known【C1】______.
   Now experiments reveal that a【C2】______ version of the gene causes energy from food to be stored as fat. Genetic tinkering in mice and on human cells in the lab suggests this can be reversed, giving hope that a drug or other【C3】______ might be developed to do the same in people.
   The discovery【C4】______ the notion that "when people get obese it was basically their own choice because they choose to eat too much or not exercise," said study leader Melina Claussnitzer, a genetics specialist. For the first time, genetics has revealed a mechanism in obesity that was not really【C5】______ before and gives a third explanation or factor that’s involved.
   Several obesity drugs are already on the market, but they are【C6】______ used for short-term weight loss and are aimed at the brain and appetite: they don’t directly target metabolism. Researchers can’t guess how long it might take before a drug【C7】______ on the new findings becomes available. But it’s unlikely it would be a【C8】______ pill that would enable people to eat anything they want without packing on the pounds. And targeting this fat pathway could affect other things, so a treatment would need【C9】______ testing to prove safe and effective.
   The gene glitch doesn’t explain all obesity. It was found in 44 percent of Europeans but only 5 percent of blacks, so other genes clearly are at work, and food and exercise still【C10】______.
【C4】
选项
答案E
解析 (challenges)从词性判断，该空格需要填入动词的第三人称单数形式。依据上文，即第一段对肥胖基因研究新发现的论述，以及下文的“gives a third explanation or factor that’s involved”，可以推断这个发现是对现有理论(肥胖由过度进食和缺乏运动引发的)的质疑，故选择challenges。
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