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  3. Founder mutations are a class of disease-causing genetic mutations, each derived from its own ancestral “founder" in whom the mu

Founder mutations are a class of disease-causing genetic mutations, each derived from its own ancestral “founder" in whom the mu

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问题     Founder mutations are a class of disease-causing genetic mutations, each derived from its own ancestral “founder" in whom the mutation originated. While most disease-causing mutations are found in humans at a rate of one in a few thousand to one in a few million people, founder mutation can occur at much higher rates. This apparent anomaly is partially explained by the fact that most founder mutations are recessive: only a person with copies of the affected gene from both parents becomes ill. Most people with only one copy of the gene—"carriers"—survive and pass the gene to offspring. Furthermore, the single copy of a founder mutation often confers a survival advantage on carriers. For example, the hereditary hemochromatosis mutation protects carriers from iron-deficiency anemia because the mutated gene allows increased efficiency of iron absorption.
The passage indicates which of the following about founder mutations?
选项 A、Carriers of founder mutation may receive certain benefits from the mutated gene.
B、People who inherit founder mutations from both parents can become ill as a result.
C、Founder mutations are less likely than other mutations to be passed to offspring.
答案A,B
解析 A对应第五六两句。B项对应第三句。C项根据文章，因为创始者突变是隐性的，所以携带者更多，更有可能传给后代。
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