首页
外语
计算机
考研
公务员
职业资格
财经
工程
司法
医学
专升本
自考
实用职业技能
登录
外语
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for H1V-AIDS. A compound, whic
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for H1V-AIDS. A compound, whic
admin
2010-09-25
34
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for H1V-AIDS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys, If the. drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical(制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV.
Those enzymes ere reverse transcriptase(转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase(整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them, integrase acts like a cut and paste operation in a word processor, deleting an immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and protease inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for," he said. "I mean, we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data, I think we would petition for fast track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chances of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and protease inhibitors, as well."
What has become standard cocktail therapy?
选项
答案
Inhibitor drugs.
解析
根据题干中的关键词standard cocktail therapy定位到第四段,可知抑制剂用于阻碍两种蛋白质,减慢感染后病情的发展,因此已经成为治疗感染HIV病毒患者的标准治疗方法,即“鸡尾酒疗法”.由此可知,成为标准鸡尾酒疗法的是抑制剂。
转载请注明原文地址:https://kaotiyun.com/show/9Fz7777K
0
大学英语六级
相关试题推荐
Achildwhohasoncebeenpleasedwithatalelikes,asarule,tohaveitretoldinidenticallythesamewords,butthisshould
Throughouthistory,peoplewithdisabilitieshaveoftenbeensubjectedtocreelandinhumantreatment.Forexample,intheearly
A、ABritishdoll.B、Herbestwhitedress.C、Herson.D、ApictureofGeorgeWashington.D事实细节题对话中明确提到白宫被烧时JamesMadison,总统的妻子救出了
A、Moremarketshare.B、JobsecurityC、IncreaseofproductionD、HigherprofitabilityD
A、Anessay,B、AmagazinearticleC、Apoem.D、Ashortstory.D该题是就学生星期三的阅读作业提问。根据短文中的YourassignmentforWednesdayistoreadHem
HitlerandhismenhadtheirhatredtowardsJewsandcolorpeople.Oursocietyisriddledwithsuchhatredbased【S1】_
A、TheGodsofRome.B、AncientBeliefs.C、TheRhythmoftheUniverse.D、GodsinOurWords.D主旨归纳题文章从solar和lunar两个词的含义由来入手介绍了古罗马神
A、Inapark.B、Inamuseum.C、Inazoo.D、Inthepetstore.D细节判断题根据对话可以得知双方正在谈论的是动物。而且根据对话中的关键词thepricetag可以判断对话发生的地点不是在动物园
A、Industry.B、Health.C、Thefutureofourchildren.D、Cleanair.A
Onlywithcombinedefforts,______.(我们才能期望我们的国家有新的面貌).
随机试题
A.HoldthelineB.flightnumberC.askaquestionD.ToNewYorkE.MayIhaveyounameF.reconfirmmyseatG.pleasechecki
A.直接促进窦前卵泡及窦状卵泡颗粒细胞的增殖与分化,使卵泡生长发育B.促进水钠排泄C.促进乳汁合成D.促进阴道上皮基底层细胞增生、分化、成熟E.在卵泡期刺激卵泡膜细胞合成雄激素,为雌二醇的合成提供底物LH的生理作用是
下列哪些属于当代中国法的正式渊源()。
土地收益测算的原则?
某建筑定时供应热水,设半容积式水加热器,采用上行下给机械循环供水方式,经计算,配水管网总容积300L,其中管内热水可以循环流动的配水管管道容积180L,系统循环流量为1080L/h,循环次数为4次/h,则回水管管道容积为()。
对于原地基处理的要求的说法正确的有()。
企业当月交纳以前各期未交的增值税,应()。
由于信息出现的顺序不同而影响印象形成的现象包括()。
科学发展观的出发点和落脚点是()。
下列各项对于太阳系的描述正确的有()。
最新回复
(
0
)