首页
外语
计算机
考研
公务员
职业资格
财经
工程
司法
医学
专升本
自考
实用职业技能
登录
外语
Scientists said Thursday that a new AIDS vaccine, the first ever declared to protect a significant minority of humans against th
Scientists said Thursday that a new AIDS vaccine, the first ever declared to protect a significant minority of humans against th
admin
2012-02-24
33
问题
Scientists said Thursday that a new AIDS vaccine, the first ever declared to protect a significant minority of humans against the disease, would be studied to answer two fundamental questions: why it worked in some people but not in others, and why those infected despite vaccination got no benefit at all.
The vaccine—known as RV 144, a combination of two genetically engineered vaccines, neither of which had worked before in humanslwas declared a qualified success after a six-year clinical trial on more than 16,000 volunteers in Thailand. Those who were vaccinated became infected at a rate nearly one-third lower than the others, the sponsors said Thursday morning.
"I don’t want to use a word like ’breakthrough,’ but I don’t think there’s any doubt that this is a very important result," said Dr. Anthony S. Fauci, the director of the National Institute of Allergy and Infectious Diseases, which is one of the trial’s backers. "For more than 20 years now, vaccine trials have essentially been failures," Dr. Fauci said. "Now it’s like we were groping down an unlit path, and a door has been opened. We can start asking some very important questions."
It will still, however, take years of work before a vaccine that could end the epidemic, which has killed about 25 million people, can even be contemplated. "We often talk about whether a vaccine is even possible," said Mitchell Warren, the executive director of the AIDS Vaccine Advocacy Coalition, or AVAC. "This is not the vaccine that ends the epidemic and says, ’O.K., let’s move on to something else.’ But it’s a fabulous new step that takes us in a new direction."
In which direction is still unknown. No one—including the researchers from the United States Army, the National Institutes of Health, the Thai Ministry of Public Health and two vaccine companies that tested the vaccine—knows why the vaccine gave even its weak indicator of success.
Experts generally disdain vaccines that do not protect at least 70 to 80 percent of those getting them. And this vaccine did not lower the viral loads of people who were vaccinated but caught the virus anyway, which was baffling because even mismatched vaccines usually do that. Simply repeating the trial to confirm the results would be pointless, experts agreed. The trial, the largest AIDS vaccine trial in history, cost $105 million and followed 16,402 Thai volunteers. The men and women ages 18 to 30 were recruited from two provinces southeast of the capital, Bangkok, from the general population rather than from high-risk groups like drug injectors or sex workers. Half got six doses of two different vaccines; half were given placebos. For ethical reasons, all were offered condoms, taught how to avoid infection and promised lifelong antiretroviral treatment if they got AIDS. They were then regularly tested for three years; 74 of those who got placebos became infected, but only 51 of those who got the vaccines did.
Although the difference was a mere 23 people, Col. Jerome H. Kim, a physician and the manager of the Anny’s H.I.V. vaccine program, said it was statistically significant and meant that the vaccine was 31.2 percent effective. The results were surprising because both vaccines, one from the French company Sanofi-Aventis and one developed by Genentech but now licensed to Global Solutions for Infectious Diseases, a nonprofit health group, had failed when used individually. "This came out of the blue," said Chris Viehbacher, Sanofi’s chief executive. Even 31 percent protection "was at least twice as good as our own internal experts were predicting," he added. In 2004, there was so much skepticism about the trial just after it began that 22 top AIDS researchers published an editorial in Science magazine suggesting that it was a waste of money.
One conclusion from the surprising result, said Alan Bernstein, head of the Global HIV Vaccine Enterprise, an alliance of organizations pursuing a vaccine, "is that we’re not doing enough work in humans." Instead of going back to mice or monkeys, he said, different new variants on the two vaccines could be tried on a few hundred people in several countries. This vaccine was designed to combat the most common strain of the virus in Southeast Asia, so it would have to be modified for the strains circulating in Africa and the United States. Sanofi’s vaccine, Alvac-HIV, is a canarypox virus with three AIDS virus genes grafted onto it. Variations of it were tested in several countries; it was safe but not protective. The other vaccine, Aidsvax, was originally made by Genentech and contains a protein found on the surface of the AIDS virus; it is grown in a broth of hamster ovary cells. It was tested in Thai drug users in 2003 and in gay men in North America and Europe but failed. In 2007, two trials of a Merck vaccine in about 4,000 people were stopped early; it not only failed to work but for some men also seemed to increase the risk of infection.
Combining Alvac and Aidsvax was simply a hunch: if one was designed to create antibodies and the other to alert white blood cells, might they work together? One puzzling result—those who became infected had as much virus in their blood whether they got the vaccine or a placebo-suggests that RV 144 does not produce neutralizing antibodies, as most vaccines do, Dr. Fauci said. Antibodies are Y-shaped proteins formed by the body that clump onto invading viruses, blocking the surface spikes with which they attach to cells and flagging them for destruction. Instead, he theorized, it might produce "binding antibodies," which latch onto and empower effector cells, a type of white blood cell attacking the virus. Therefore, he said, it might make sense to screen all the stored Thai blood samples for binding antibodies. "The humbling prospect of this," he said, "is that we may not even be measuring the critical parameter. It may be something you don’t normally associate with protection." Dr. Lawrence Corey, the principal investigator for the HIV Vaccine Trials Network, who was not part of the RV 144 trial, said new work on weakened versions of the smallpox vaccine had produced better pox "spines" that could be substituted for the canarypox. New trials, he added, could be faster and smaller if they were done in African countries where AIDS is more common than in Thailand.
Which of the following can be used to describe the finding of RV 144?
选项
A、unexpected
B、expected
C、controversial
D、insignificant
答案
A
解析
此题是事实题。由第十段可知,RV144是凭着直觉被发现的,因此是意料之外的。
转载请注明原文地址:https://kaotiyun.com/show/NziO777K
0
专业英语八级
相关试题推荐
Doyouhaveamaximorimportantstatementthathelpsyouguideyourlife?Writeanessaystatingyourmaximandhowitisimpor
Recently,apossiblealternativewayofproducingpaperhasbeensuggestedbyagriculturalists:andenvironmentalists:aplant
IntheAustralianstateofNewSouthWales,agovernmentsponsorsurveyrevealedsomeshockingstatisticsregarding【1】_
IntheAustralianstateofNewSouthWales,agovernmentsponsorsurveyrevealedsomeshockingstatisticsregarding【1】_
A、Thestrikehasresultedinagreatlosstotheminingindustry.B、Afewreporterswereallowedtoapproachthemine.C、Halfth
HowtheSmallpoxWarWasWonTheworld’slastknowncaseofsmallpoxwasreportedinSomalia,theHornofAfrica,inOctober
HowtheSmallpoxWarWasWonTheworld’slastknowncaseofsmallpoxwasreportedinSomalia,theHornofAfrica,inOctober
TheRoslinInstituteannouncedlastweekthatithadappliedtopatentthemethodbywhichitsscientistshadclonedDollythes
TheRoslinInstituteannouncedlastweekthatithadappliedtopatentthemethodbywhichitsscientistshadclonedDollythes
TheSkillsofEssayWritingWritingcanhelpyoutogetyourthoughtsclear,toexploresomeofyourideasandto【1】yourself
随机试题
监护脐带先露或脐带脱垂的手段包括下列哪些项目:
A苏子降气汤B.小青龙汤C.六君子汤D.参苓白术散E.二陈平胃散治疗痰浊壅肺型肺胀的首选方是
女性,32岁,间断发热1个月,无消瘦、贫血,无咳嗽、咳痰、咽痛。查心、肺、腹无明显阳性体征,但心肌酶升高,肝肾功能轻度异常,尿蛋白(++),下列检查更具诊断意义的是
28岁初孕妇,妊娠35周,自述剧烈腹痛伴发热、恶心、呕吐半日就诊。B型超声见子宫如妊娠35周,于宫底偏左有一超手拳头大肌瘤。查血白细胞总数为14.4×109/L。在急诊室,告诉患者应人院并需做的处置是
张三、李四、王五成立天问投资咨询有限公司,张三、李四各以现金50万元出资,王五以价值20万元的办公设备出资。张三任公司董事长,李四任公司总经理。公司成立后,股东的下列哪些行为可构成股东抽逃出资的行为?()
政府行政监督的特点具体表现在( )。
下列关于BOT模式说法不准确的是()。
基金管理人、基金托管人从事基金管理活动取得的收入,()。
阅读材料,回答下列问题: 小芹是初中二年级的女生,智力正常,人际关系良好,上课和平时作业都比较认真,学习总体成绩在班级处于中等水平,但是自信心有些不足。这次期中考试,她的其他课程考试发挥正常.只有数学没有考及格。她认为数学没有考好是因为她比别人笨,即使她
Mostpeoplewhotravellongdistancecomplainofjetlag.Jetlagmakesbusinesstravelerslessproductiveandmoreprone【C1】____
最新回复
(
0
)