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  3. _____is known to all, too much stress can cause disease.

_____is known to all, too much stress can cause disease.

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问题 _____is known to all, too much stress can cause disease.
选项 A、Which
B、That
C、It
D、As
答案D
解析 分析句子结构可知，逗号之前为非限制性定语从句，指代后面句子的内容。从句成分不完整，缺少主语，所以应用关系代词as来引导。which引导的非限制性定语从句不可位于句首；it，that均不能引导非限制性定语从句。也可将as is known to all(众所周知)当作固定搭配。类似的用法还有as is often the case(情况往往是这样)，as often happens(事情往往如此)，as is mentioned above(正如上面所提到的)等。故选D。
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