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Scientists have identified a new way of fighting cancer that limits the growth and spread of a variety of tumors in laboratory animals.
    When you get a cut, the area quickly becomes inflamed—swollen, red, and tender as the body’s immune system sends white blood cells to fight infection and heal the wound.
    The immune system reacts to many cancers in much the same way, says University of California, San Diego researcher Judith Varner.
    That happens when the immune system cells are ’ hijacked’ by the tumor in a way that fosters the growth and spread of tumors.
    Varner and her colleagues identified a specific enzyme called PI-3 kinase gamma that allows the immune cells to get into the tumor, where it can be compromised. They figured out how to block PI-3 kinase gamma, using either drugs or genetic methods, in laboratory mice.
    In addition to the mice with breast cancer, the researchers also used this approach on a variety of other cancers in laboratory animals and found it was consistently effective across a range of different kinds of tumors.
    Varner says suppressing PI-3 kinase gamma might in theory also be effective to reduce the risk of cancer in the first place, in cases where chronic inflammation contributes to tumor formation.
    She says human testing of PI-3 kinase gamma inhibitors to battle cancer could begin as soon as a year or so from now.