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  3. In the past 20 years alone, three coronaviruses have caused major disease outbreaks. First came the original SARS virus in 2002.

In the past 20 years alone, three coronaviruses have caused major disease outbreaks. First came the original SARS virus in 2002.

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问题     In the past 20 years alone, three coronaviruses have caused major disease outbreaks. First came the original SARS virus in 2002.【C1】________. in 2012, MERS was identified. In 2019, SARS-CoV-2【C2】________.
    Hundreds of other coronaviruses are known to be【C3】________in bats and other animals. Scientists have warned that some of them could arise in the future and【C4】________infect people. Our current COVID-19 vaccines were specifically【C5】________for SARS-CoV-2, but what if a next-generation vaccine could protect【C6】________both known and unknown coronaviruses?
    Scientists at the Walter Reed Army Institute of Research are working on a so-called universal coronavirus vaccine. Dr. Kayvon Modjarrad is【C7】________the effort. They have developed a vaccine specifically for SARS-CoV-2, and found that the immune response that it【C8】________is active against all the variants, as well as other coronaviruses like SARS-CoV-1. And this gives them confidence that it can be a platform for the entire coronavirus family.
    The vaccine is known as SpFN, which combines nanoparticles from ferritins with coronavirus spike proteins. But making the vaccine wasn’t as【C9】________as attaching one protein to another. Modjarrad and his colleagues had to【C10】________which parts of the spike to attach to which type of ferritin and how to【C11】________the two proteins together. It took months of trying more than 200 different【C12】________. By June of last year, the team found one version that succeeded where others had failed. They then【C13】________the experimental vaccine in mice and monkeys.
    The team also turned to less【C14】________animals for testing. Working with scientists in India, they【C15】________horses with the vaccine to learn how strong the【C16】________response was. And they【C17】________with Helen Dooley at the University of Maryland to vaccinate sharks—which make special antibodies.
    The results are【C18】________. but animals aren’t people. The Army vaccine is now being tested in a small, early-stage trial in humans.【C19】________it works and is safe, it could lay the【C20】________for a universal coronavirus vaccine.
【C1】
选项 A、But
B、Then
C、Instead
D、Soon
答案B
解析 文章首句讲到3种冠状病毒造成的重大疾病暴发，随后对这3种病毒逐一进行介绍，从2002、2012、2019可以看出明显的时间顺承关系，故本题选择时间顺承关系词then，因此选项B为答案。A项意思是“但是”，表示转折关系；C项意思是“相反”，表示否定关系；D项意思是“不久”，与原文中2002年到2012年的时间跨度不符。三项都不符合原文逻辑关系，故全部排除。
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